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Properties
| Related Categories | Angiotensins, Application Index, Cell Signaling Enzymes, Chymase and Related Products, Neuropeptides, |
| assay | ≥93% (HPLC) |
| form | powder |
| total impurities | 1.2-10.4% acetate |
| storage temp. | −20°C |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... AGT(183) |
Description
Amino Acid Sequence
Asp-Arg-Val-Tyr-Ile-His-P
Antibody Adsorbant
Asp-Arg-Val-Tyr-Ile-His-P
Analysis Note
Peptide content not less than 75%
Biochem/physiol Actions
Angiotensin (Ang) II is important in regulating cardiovascular hemodynamics and cardiovascular structure. Most of the known effects of Ang II in adult tissues are attributable to the angiotensin II type I (AT1) receptor. The AT1 and AT2 receptors have differential pharmacological and biochemical properties and appear to exert opposite effects in terms of cardiovascular hemodynamics and cell growth. In addition, the renin-angiotensin and nitric oxide-generating systems appear to interract in the regulation of cardiovascular function. Ang II stimulates angiogenesis and increases microvessel density. In nature, angiotensin II is produced by the action of angiotensin converting enzyme on angiotensinogen; the C-terminal-His-Leu is cleaved.
Price and Availability
Customers Also Purchased
powder, ≥98% (HPLC)
Documents
Certificate of Analysis
Certificate of Origin
| A9525 - Datasheet (80 KB) |
| Celltransmissions 19(1) (143 KB ) |
| Angiotensin Receptors (178 KB ) |
| Angiotensin Receptors (81 KB ) |
| Neuropeptidases (252 KB) |
| Neuropeptidases Classification (197 KB ) |
| Gene Information |
| Similar Products |
Safety Information
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
| RTECS | BW2165000 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
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References
Inagami, T, et al., The renin-angiotensin system: an overview of its intracellular function. Cardiovasc. Drugs Ther. 2, 453-458, (1988) Abstract
Fernandez-Alfonso, M.S., and Gonzalez, C., Nitric oxide and the renin-angiotensin system. Is there a physiological interplay between the systems? J. Hypertens. 17, 1355-61, (1999) Abstract
Xoriuchi, M., et al., Cross talk between angiotensin II type 1 and type 2 receptors: cellular mechanism of angiotensin type 2 receptor-mediated cell growth inhibition. Hypertens. Res. 22, 67-74, (1999) Abstract
Inagami, T. et al., Angiotensin receptors: molecular biology and signaling. Clin. Exp. Pharmacol. Physiol. 26, 544-549, (1999) Abstract
Yongzhong, W., et al., Angiotnesin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells. J. Biol. Chem. 281, 35137-35146, (2006) Abstract
Takeshige, K., et al., Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 114, 953-960, (2006) Abstract
Fan, H., et al., Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression. Mol. Immunol. 44, 3092-9, (2007) Abstract
Yang, X., et al., Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation. J. Histochem. Cytochem. 26, 1629-35, (2008)
Sendra, J., et al., Angiotensin II upregulates LDL receptor-related protein (LRP1) expression in the vascular wall: a new pro-atherogenic mechanism of hypertension. Carcinogenesis 78, 581-9, (2008)
Hauck, L., et al., Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart. Nat. Med. 14, 315-24, (2008) Abstract
DeWire, S.M., et al., Beta-arrestin-mediated signaling regulates protein synthesis. J. Bacteriol. 283, 10611-10620, (2008)
Hsu, H.H., et al., Mechanisms of angiotensin II signaling on cytoskeleton of podocytes. J. Mol. Endocrinol. 86, 1379-94, (2008)
Zhao, Z.S., et al., Mouse hepatic portal venoconstrictive response to vasoconstrictors is much weaker than that in rat. J. Cardiovasc. Pharmacol. 54, 421-6, (2009) Abstract
Cheng, C., et al., Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype. Atherosclerosis 204, 26-33, (2009) Abstract
Xanthoulea, S., et al., Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice. PLoS Biol. 4, e6113, (2009)
Pelisch, N., et al., Systemic Candesartan Reduces Brain Angiotensin II Via Downregulation Of Brain Renin-angiotensin System. Hypertens. Res. 33, 161-4, (2010) Abstract
Rigel, D.F., et al., Pharmacodynamic And Pharmacokinetic Characterization Of The Aldosterone Synthase Inhibitor FAD286 In Two Rodent Models Of Hyperaldosteronism: Comparison With The 11beta-hydroxylase Inhibitor Metyrapone. J. Nutr. 334, 232-43, (2010)
Xanthoulea, S., et al., Absence Of P55 TNF Receptor Reduces Atherosclerosis, But Has No Major Effect On Angiotensin II Induced Aneurysms In LDL Receptor Deficient Mice. PLoS ONE 4, e6113, (2009) Abstract
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